Feature description:
The cell reactor is used to complete the cell culture process from seed expansion to production culture, including the transfer and mixing of various materials, the precise control and display of temperature, pressure, pH, DO (dissolved oxygen), foam, liquid level and volume as well as the amount of alkali replenishment, replenishment volume, replenishment rate, the aseptic filtration, measurement and display of incoming air, oxygen, carbon dioxide and nitrogen (if any), the good control of condensation, heating and aseptic filtration of exhaust , the necessary online cleaning and sterilization operations during the production process, etc.
The ability to meet the temperature, pressure, pH, DO, foam and other requirements of existing production processes at the maximum working volume. The control of liquid level, cell density increased 5-15 times in 48h-72h after inoculation of CHO cells, with densities of 2.0×105Cells/mL-4.0×107Cells/mL. All parameters of the tank can be controlled.
The cell culture process from seed expansion to production culture, including the transfer and mixing of various materials, the precise control and display of temperature, pressure, pH, DO (dissolved oxygen), foam, liquid level and volume, as well as the amount of alkali replenishment, the amount of replenishment, the rate of replenishment, the aseptic filtration, measurement and display of added air, oxygen, carbon dioxide, nitrogen (if any); good control of the condensation, heating and aseptic filtration of emissions; the necessary online cleaning and sterilization operations in the production process.
| Speed control |
Intelligent automatic PID control, pulse width modulation rare earth DC motor +
gearbox, stirring speed: 50-1000rpm, variable speed, accuracy ± 5 ‰ |
| DO control |
PID intelligent automatic control, imported Swiss electrodes and cables,
measuring range: 0-150%, control accuracy: ± 3%. Resolution 0.1%,
according to the fermentation process controlled by fermentation time
sequence(DO automatic variable control, multi-segment), can associated
control with speed, air flow, pressure, feeding and other parameters |
| PH control |
Intelligent PID automatic control, imported Swiss electrodes and cables, two peristaltic pumps.
Display range: 0.00 to 14.00 ± 0.01, control range: 2.00 to 12.00 ± 0.02.
Online detection, automatic alarm, automatically add acid/alkali solution by peristaltic pump
pH value curve analysis, acid/alkali volume curve analysis, quantitative analysis batch report,
The cumulative amount of acid/alkali added display records,
Control the fermentation process by fermentation time sequence
(pH automatic variable controller, multi-segment) |
| Temperature control |
Intelligent PID automatic control, thermostatic bath + PT100 temperature
sensor + electric heating + solenoid valve range; cooling water
temperature +3 -60 ºC, accuracy of ± 0.2 ºC, 0.1 ºC resolution |
| Feeding control |
Air ratio control switch can be set to 1-100%, automatic flow and measured.
Supplement feeding amount curve analysis, the amount accumulated,
display records, save of batch reports analyze.
Control the fermentation process segment by fermentation time
sequence(automatic feeding variables, multi-segment) .
Dedicated pins and needles feeding sets, to ensure safe operation of feeding. |
| Defoaming control |
Intelligent PID automatic control, electrode detection, adding defoamer by
peristaltic pump, sensitivity 100-100000Ω, can supplement quantitative and timing. |
| Ventilation |
Manual adjustment, the flow meter measure, ventilation 1: 1-2VVM |
| Pressure |
Manual adjustment, pressure gauge measure ,the range 0-0.2MPa |
| Sterilization |
Manual adjustment, the program assisted sterilization, sterilization reign / off-site. |
| Control system |
Based on the German scene controller S7-200 Siemens programmable logic
controller series as the core. Imported 5.7 "true color touch screen.
Independent control software, matte stainless steel control cabinet.
Data processing can be performed and the curve displayed
Data A / D or D / A conversion, data capture to display, each control loop tuning
PID operation and setpoint control, timing control and host communications. |
|
Exhaust |
Stainless steel exhaust condenser exhaust |
| Function |
|
PC remote control
Automatic sterilization
Exhaust O2, CO2 detection
Oxidation-reduction detection
Automatic ventilation
Automatic tank pressure
Tank Weighing
Feeding Weighing
Online precisely calculated important parameters
OUR, CER, RQ, KLα, etc.,which indirectly reflect
the changes in cell metabolism stream.
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Features
1. With low shear force and good mixing effect, it can meet the requirement of free suspension cell culture.
2. Equipped with aself-cleaning liquid change tube, which can meet the requirement of up to 5 times the culture volume flow per day under continuous culture conditions without clogging.
3. Unique bubble-free ventilation device. Completely solve the damage of air bubbles to cells under various culture conditions, and at the same time reach the oxygen transfer rate of 10ml/L/Hr to meet the requirements of high density culture.
4. Innovative sterilization sampling device. In any case, you can sample, observe, and test.
5. All connections are hygienic, simple and convenient.
6. Combination of surface ventilation and deep ventilation.
7. The open design of pipes and pipe racks is convenient for use and maintenance.
8. The control system uses industrial programmable logic control elements from Siemens. The system is open and can replacedamaged modules online.
9. The parameter control adopts deviation tolerance control, and the control parameters are stable without fluctuation.
10. Two stable reference points are adopted for stability, and the temperature is stable and reliable.
11. The stirring speed can be set as a function of time to meet the requirements of stirring speed in different cultivation periods.
12. The software system has the function of automatically diagnosing each subsystem, which is convenient for overhaul and maintenance.
13. Control is based on Windows Ce operating system, simple and easy to learn.
14. Comply with GMP/cGMP requirements.
We can produce many production lines, such as:
Insulin production line/fermentation tank equipment (including all technical services and cooperation)
Vaccine production line/fermentation tank equipment (including all technical services and cooperation)
Antibiotic production line/fermentation tank equipment, (including all technical services and cooperation)
Lysine production line/fermentation tank equipment, (including all technical services and cooperation)
Glucose production line/fermentation tank equipment (including all technical services and cooperation)
Citric acid production line/fermentation equipment (including all technical services and cooperation)
Amoxicillin production line/fermentation equipment (including all technical services and cooperation)
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages
Company Profile:
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the Sinopharm authorization to sell its intermediates and APIs,and has the Sinopharm of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
1. Are you a factory or a trading company?
Answer: We are a factory.
2. What is MQQ?
Answer: 1 unit.
3. Do you provide overseas services?
Answer: Yes, we can send engineers overseas.
4. Can we visit your factory?
Answer: Yes, you are very welcome.
5. What is your delivery time?
Answer: 2 weeks to 3 months. It depends on the size and quantity.
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