| Customization: | Available |
|---|---|
| Application: | Penicillin Antibacterial |
| Usage Mode: | for Injection |
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Item Name:
Ingredients
The main composition and chemical name of this product are:
Piperacillin sodium;(2 s, 5 r, 6 r) - 3.3 - dimethyl - 6 - [(4 - ethyl - 2, 3-2-1 - piperazine oxygen generation formyl amine) amino] phenylacetyl - 7-4 - sulfur impurity oxygen generation - - 1 - nitrogen mixed double loop [3.2.0] heptane - 2 - formic acid sodium salt.
Its structural formula is as follows:
Molecular formula: C23H26N5Nao7S
Molecular Weight: 539.54
Character
This product is white or quasi-white powder or loose lumps;Odourless;It is easy to get wet.
Indications
Suitable for sepsis caused by sensitive enterobacteriaceae bacteria, pseudomonas aeruginosa, acinetobacter, upper urinary tract and complicated urinary tract infection, respiratory tract infection, biliary tract infection, abdominal cavity infection, pelvic cavity infection, skin and soft tissue infection, etc.Piperacillin in combination with aminoglycosides can also be used for infection in immunocompromised patients with granulocytopenia.
Specifications
C23H27N5O7S calculation (1)0.5g;(2) 1.0 g;(3) 2.0 g.
Usage.
This product is available for intravenous infusion and intravenous injection.
For adults with moderate infection, 8g per day was given intravenously in 2 times.Severe infection 3 ~ 4g once, intravenous drip or injection every 4 ~ 6 hours.The total daily dose shall not exceed 24g.
The dose for infants and children under 12 years of age is 100 to 200mg/kg per day according to body weight.Neonatal weight less than 2kg, the first week after birth every 12 hours 50mg/kg, intravenous infusion;From the second week, 50mg/kg, once every 8 hours.50mg/kg intravenously every 8 hours in the first week after birth for newborns weighing more than 2kg;50mg/kg every 6 hours for more than 1 week.
Adverse reactions
1.Allergic reactions: Penicillin drug allergic reactions are more common, including urticaria and other types of rash, leucopenia, interstitial nephritis, asthma attacks and serum disease type reactions, such as anaphylactic shock occasionally seen in severe cases;Once anaphylactic shock occurs, emergency treatment must be carried out on the spot, with airway unblocked, oxygen inhalation, epinephrine, glucocorticoid and other treatment measures.
2.Local symptoms: pain at the local injection site, thrombophlebitis, etc.
3.Gastrointestinal symptoms: diarrhea, loose stools, nausea, vomiting, etc.Pseudomembranous enteritis is rare.
4.Individual patients may have cholestatic jaundice.
5.Central nervous system symptoms: headache, dizziness, fatigue, etc.
6.In patients with reduced renal function, penicillin encephalopathy may occur due to increased concentration of cerebrospinal fluid (CSF), so dose adjustment should be made according to renal function.
7.Others: Candida double infection, bleeding, etc.
taboo
It is contraindicated for patients with penicillin allergy or positive penicillin skin test.
Matters needing attention
1.Before using this product, it is necessary to inquire about the history of drug allergy and conduct penicillin skin test. Positive reaction is prohibited.
2.People who are allergic to one type of penicillin may be allergic to other penicillin drugs;People who are allergic to cephalosporins, cephalomycin, griseofulvin or penicillamine may also be allergic to this product.
3.This product can cause bleeding in a few patients, especially in patients with renal insufficiency. After the occurrence, the drug should be stopped in time and given appropriate treatment.The dose should be reduced appropriately in patients with renal dysfunction.
4.Interferences to diagnosis: the application of this product can cause direct antiglobulin (COOMBS) test positive, also may occur blood urea nitrogen and serum creatinine, hypernatremia, hypokalemia, serum aminotransferase and serum lactate dehydrogenase increase, serum bilirubin increase.
5.It should be used with caution in patients with a history of allergy, bleeding, ulcerative colitis, clonosis, or antibiotic-related colitis.
6.This product should not be added to sodium bicarbonate solution.
Pregnant women and lactating women
No harm was found in animal reproductive tests, but strict controlled trials have not been carried out in pregnant women to rule out adverse effects of such drugs on the fetus, so pregnant women should use this product only when it is really necessary.A small amount of this product is secreted from milk, lactating women use drugs to stop breastfeeding.
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