Item nanme:Domperidone Teblets Item character: This product is white.
Indication:
1. Dyspepsia caused by delayed gastric emptying, gastroesophageal reflux and esophagitis.
-Abdominal distension and pain;
-Warm gas, flatulence;
-Nausea and vomiting;
-Gastric burning sensation with or without reflux gastric contents in the mouth.
2. Nausea and vomiting caused by functional, organic, infectious, dietary, radiotherapy or chemotherapy. Dopamine receptor agonists (such as levodopa, bromocriptine, etc.) are the specific indications for the treatment of nausea and vomiting caused by Parkinson's disease.
Item specifications:10mg (30units)
Usage and dosage: Oral administration.
Adult: 3-4 times a day, 1 tablet each time. If necessary, double the dose or follow the doctor's advice.
Children (over 12 years old and over 35 kg): 3-4 times a day, 0.3 mg / kg body weight each time.
This product should be taken 15-30 minutes before meals, if taken after meals, absorption will be delayed.
The maximum daily dose is 80 mg.
Adverse reactions
IAccording to the following standard practice of incidence rate: very common (> 1 / 10); common (> 1 / 100, < 1 / 10); rare (> 1 / 1000, < 1 / 100); rare (> 1 / 10000, < 1 / 1.000); very rare (< 1 / 10000), including individual cases, the adverse reactions were sorted according to the incidence rate:
Immune system:
Very rare: anaphylactic reactions including anaphylactic shock, angioneurotic edema, anaphylactic reactions, endocrine:
Endocrine:
Rare: elevated prolactin levels
Mental system:
Rare: excitement, nervousness
Nervous system:
Very rare: extrapyramidal side effects, convulsions, drowsiness, headache
Gastrointestinal tract:
Rare: gastrointestinal discomfort, including very rare transient enterospasm
Skin and subcutaneous tissue:
Very rare: rash, itching, urticaria
Reproductive system and mammary gland
Rare: galactorrhea, male breast feminization, amenorrhea
Examination:
Very rare: abnormal liver function test
Because the pituitary gland is located outside the blood-brain barrier, domperidone may cause prolactin levels to rise. In rare cases, this hyperprolactinemia may cause neuroendocrine side effects, such as galactorrhea, feminization of male breasts, amenorrhea.
Extrapyramidal symptoms are very rare in children, especially in adults. These symptoms can completely recover after drug withdrawal.
Other central nervous system related reactions, such as convulsions, excitement and drowsiness, are rare and are mainly reported in infants and children..
Taboo:
This product is prohibited in the following conditions:
·Known to be allergic to domperidone or any component of the product.
·Increased gastric motility can be dangerous when, for example, gastrointestinal bleeding, mechanical obstruction, perforation.
·A patient with pituitary tumor (prolactinoma) secreting prolactin.
·Combination of ketoconazole oral preparations, erythromycin or other CYP3A4 enzyme inhibitors that may prolong QTc interval, such as fluconazole, voriconazole, clarithromycin, amiodarone, thalamycin
Matters needing attention:
-This product contains lactose and may not be suitable for patients with lactose intolerance, galactosemia or impaired glucose / galactose absorption.
-When antacids or drugs inhibiting gastric acid secretion are combined with this product, the first two drugs should not be taken before meals, but after meals, that is, they should not be taken with this product at the same time.
-Because domperidone is mainly metabolized in the liver, patients with liver dysfunction are afraid to use it.
-The elimination half-life of domperidone in patients with severe renal insufficiency (serum creatinine > 6 mg / 100mL, i.e. > 0.6 mmol / L) increased from 7.4 hours to 20.8 hours, but its plasma concentration was lower than that in healthy volunteers. Because there are very few prototype drugs excreted through the kidney, it may not be necessary to adjust the dosage for patients with renal insufficiency. However, when repeated administration is required, the frequency of taking medicine should be reduced to 1-2 times a day according to the severity of renal impairment, and the dosage should be reduced at the same time. Such patients should be checked regularly when taking medicine for a long time.
-Please keep it away from children.
Medication for pregnant and lactating women: Pregnant women: This product has limited experience in pregnant women. Its potential harm to human body is unclear. However, in a study with rats, domperidone showed reproductive toxicity at a higher dose (40 times the recommended dose for human body) to the mother. Therefore, for pregnant women, only after weighing the pros and cons, can we use this product cautiously.
Lactation: the concentration of domperidone in breast milk of lactating women is 10-50% of the corresponding plasma concentration, but the concentration in breast milk will not exceed 10NG / ml. The total amount of domperidone in breast milk of lactating women is less than 7ug / day when taking the most recommended dose of domperidone. It is not known whether it will cause harm to the newborn. Therefore, lactating women in the period of taking this product, it is recommended not to breast-feeding.
FAQ 1.who are we? We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.
2. how can we guarantee quality? Always a pre-production sample before mass production; Always final Inspection before shipment;
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Our Service a) Free amples can be provided. b) Guide customers through professional technology and teach them how to use our products after sale c) Determine the lowest price of high-quality products 1. Skilled experience: Our company is a leading manufacturer of professional production in Chinapharmaceutical field for manyyears. 2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you. 3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freightforwarder. 4. Fast delivery: We have stock, so once payment is received, we can deliver quickly. 5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours. 6. Competitive price: discounts will be obtained when making large orders.
Our Manufacture Factory Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
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