Ofloxacin Tablets for Genitourinary System Infection: Acute Cystitis, Acute Pyelonephritis

Product Details
Customization: Available
Transport Package: Carton
Specification: 20x15x15cm
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Number of Employees
41
Year of Establishment
2000-12-07
  • Ofloxacin Tablets for Genitourinary System Infection: Acute Cystitis, Acute Pyelonephritis
  • Ofloxacin Tablets for Genitourinary System Infection: Acute Cystitis, Acute Pyelonephritis
  • Ofloxacin Tablets for Genitourinary System Infection: Acute Cystitis, Acute Pyelonephritis
  • Ofloxacin Tablets for Genitourinary System Infection: Acute Cystitis, Acute Pyelonephritis
  • Ofloxacin Tablets for Genitourinary System Infection: Acute Cystitis, Acute Pyelonephritis
  • Ofloxacin Tablets for Genitourinary System Infection: Acute Cystitis, Acute Pyelonephritis
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Basic Info.

Model NO.
CF071-1
Trademark
FUL
Origin
China
Production Capacity
100000/Month

Product Description

[Drug name]



Common name: ofloxacin tablets



Product name: ofloxacin tablets



Ofloxacin Tablets



Yangfushaxingpian (Kerui)



Main ingredients The main ingredient is ofloxacin. Its chemical called (+) - 9 - hydrogen fluoride - 2, 3-2-3 - methyl - 10 - (4 - methyl - 1 - piperazine) - 7 - oxygen generation - 7 h - pyridine and [1, 2, 3 - DE] - [1, 4] oxazine benzene and 6 - carboxylic acid.



"Into a"



Molecular Weight: C18H20FN3O4



[Characteristics] This product is a white film clothing piece, after removing the film clothing appears white or slightly yellow.



This product is suitable for the following infections caused by sensitive bacteria: 1. Respiratory tract infections: chronic bronchitis, bronchiectasis, acute bronchitis and pneumonia. 2. Genitourinary system infection: acute cystitis, acute pyelonephritis, complicated urinary tract infection, chronic urinary tract infection, acute attack, etc.



[Specification model] 0.1G * 10S



1. Bronchial infection and pulmonary infection: 0.3g (3 tablets) once, twice a day, a course of treatment of 7-14 days. 2. Acute simple lower urinary tract infection: 0.2g(2 tablets) once, twice a day, course of treatment 5-7 days; Complicated urinary tract infection: 0.2g per dose (2 tablets). The treatment course was 10-14 days, twice a day. 3. Prostatitis: 0.3g(3 tablets) once, twice a day, course of treatment for 6 weeks; Chlamydia cervicitis or urethritis, 0.3g (3 tablets) once, twice a day, course of treatment 7-14 days. 4. Simple gonorrhea: 0.4g (4 tablets) at a time, single dose.



1. Gastrointestinal reactions: abdominal discomfort or pain, diarrhea, nausea or vomiting. 2. Central nervous system reactions may include dizziness, headache, drowsiness or insomnia. 3. Allergic reaction: rash, skin itching, and occasionally exudative polyerythema and angioneurotic edema. Photosensitive reaction is less present. 4. Occasionally: (1). Epileptic seizure, mental disorder, restlessness, confusion, juvenile sensation, tremor. (2). Symptoms of interstitial nephritis, such as hematuria, fever and rash. (3) Phlebitis. (4). Crystallized urine, more common in high dose application. (5) Joint pain. 5. In a few patients, the increase of serum aminotransferase, blood urea nitrogen and the decrease of peripheral blood leukocytes may occur, most of which are mild and transient.



[contraindication] It is contraindication for patients allergic to this product and fluoroquinolones.



1. Since it is common that Escherichia coli is resistant to fluoroquinolones, urine culture specimens should be taken before administration, and medication should be adjusted according to the bacterial drug sensitivity results. 2. Crystallization urine may occur when the product is applied in large doses or the urine pH value is above 7. In order to avoid the occurrence of crystallizing urine, it is advisable to drink more water and keep the urine volume for 24 hours above 1200ml. 3. For patients with reduced renal function, the dosage should be given according to the renal function. 4. Overexposure to sunlight should be avoided when applying this product. If photosensitive reaction occurs, the drug should be discontinued. 5. When liver function decreases, if it is severe (cirrhosis ascites), drug clearance can be reduced, blood drug concentration increases, especially in cases of liver and renal function decrease, so it is necessary to weigh the advantages and disadvantages and adjust the dose. 6. People with pre-existing central nervous system diseases, such as epilepsy and a history of epilepsy, should avoid the application. When there is a finger, it should be used after carefully weighing the advantages and disadvantages. Please read the instructions carefully and follow the doctor's advice.



The safety of this product in infants and young people under 18 years of age has not been determined. However, this product can cause joint disease when used in several young animals. Therefore, it should not be used for children and adolescents under 18 years old.



[Elderly patients with medication] Elderly patients often have decreased renal function, because part of this product is discharged through the kidney, it is necessary to reduce the amount of application.



[Medication of pregnant women and lactating women] Animal experiments have not confirmed the teratogenic effect of quinolones, but the study on medication of pregnant women has no clear conclusion. In view of this drug can cause joint lesions in young animals, it is forbidden for pregnant women, and breastfeeding should be suspended when lactating women apply this product.



[Drug Interaction] 1. Alkalinizing agents can reduce the solubility of this product in urine, resulting in crystalline urine and nephrotoxicity. 2. When quinolone antibiotics are combined with theophylline, the competitive inhibition of the binding site with cytochrome P450 may result in significantly reduced liver elimination of theophylline, prolonged blood elimination half-life (t1/2β), increased blood drug concentration, and the appearance of theophylline poisoning symptoms, such as nausea, vomiting, tremor, agitation, agitation, convulsions, palpitations, etc. Although this product has little effect on theophylline metabolism, it is still necessary to measure theophylline blood concentration and adjust the dosage when it is used together. 3. This product combined with cyclosporine can increase the blood concentration of cyclosporine, it is necessary to monitor the blood concentration of cyclosporine and adjust the dose. 4. Although the anticoagulant effect of warfarin is less enhanced when combined with this product, the prothrombin time of the patients should be closely monitored. 5. Prosulfonate can reduce the secretion of this product from renal tubules by about 50%. When used in combination, it may cause toxicity due to increased blood concentration of this product. 6. This product can interfere with caffeine metabolism, resulting in reduced caffeine elimination, prolonged blood elimination half-life (t1/2β), and possible central nervous system toxicity. 7. The acid medicine containing aluminum and magnesium can reduce the oral absorption of this product, so it is not suitable for use.



[Drug overdose] is not clear.



[Pharmacology and Toxicology] This product has a broad spectrum of antibacterial activity, especially high antibacterial activity against aerobic gram-negative bacilli, and has good antibacterial action against the following bacteria in vitro: Most of the bacteria in the Enterobacteriaceae family include Enterobacteriaceae, such as Acidobacteriaceae, Caculosis, Aerogenic Enterobacteriaceae, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. It also has antimicrobial activity against multi-drug resistant bacteria. Serrella gonorrhoeae, Haemophilus influenzae and Moraxella resistant to penicillin all showed high antimicrobial activity. It has antibacterial effect on most strains of Pseudomonas aeruginosa. This product has antimicrobial activity against methicillin-sensitive staphylococcus, and has only moderate antimicrobial activity against pneumococcus, hemolytic streptococcus and enterococcus faecalis. It has good antimicrobial effect on Plasma trachomatis, Mycoplasma and Legionella, and also has antimicrobial activity against Mycobacterium tuberculosis and Mycobacterium SARS. The antimicrobial activity against anaerobe is poor. Ofloxacin is A fungicide that inhibits DNA synthesis and replication by acting on the A subunit of bacterial DNA helicase, leading to bacterial death.



[Pharmacokinetics] After oral administration, the absorption is complete, and the relative bioavailability is 95%-100%. Blood drug peak time (Tmax) is about 1 hour. Food has little effect on the absorption of the product. Steady-state plasma concentration (CSS) was achieved approximately 3 days after multiple dosing. The blood elimination half-life (t1/2β) was about 4.7 ~ 7.0 hours, and the protein binding rate was 20% ~ 25%. After absorption, the product is widely distributed to various tissues and body fluids. The concentration in tissues often exceeds the blood drug concentration and reaches the effective level. This product can also pass the placental barrier. This product is mainly excreted from the kidney in its original form, and a small amount (3%) is metabolized in the liver. Within 24 hours of oral administration, 75% ~ 90% of the drug dose is excreted in urine, and there are few metabolites in urine. A small amount of the product was excreted from the stool in its original form, and the cumulative excretion was 1.6% and 3.9% of the dose 24 and 48 hours after administration, respectively. This product can also be secreted through milk.



To preserve in sealed storage.



[Effective period] 24 months



[Approval Number] National medicine approval H50020298




FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese


Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages

Our Service
a)  Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.


Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.



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Ofloxacin Tablets for Genitourinary System Infection: Acute Cystitis, Acute Pyelonephritis
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Ofloxacin Tablets for Genitourinary System Infection: Acute Cystitis, Acute Pyelonephritis
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Ofloxacin Tablets for Genitourinary System Infection: Acute Cystitis, Acute Pyelonephritis

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