Item nanme:Loxoprofen Sodium Tablets Item character:This product is light pink
Indication:
The following diseases and symptoms of anti-inflammatory and analgesic
Rheumatoid arthritis, osteoarthritis, low back pain, periarthritis of shoulder, neck shoulder wrist syndrome.
Analgesia and anti inflammation after operation, trauma and tooth extraction.
Antipyretic and analgesic for the following diseases
Acute upper respiratory tract inflammation (including acute upper respiratory tract inflammation with acute bronchitis).
Item specifications: 60mg*20tab/box
Usage and dosage:(1) and (2) hours of indication:
In general, loxoprofen sodium (as anhydrous substance) is given orally to adults once a day, three times a day. When symptoms appear, take orally 60-120 mg once.
It should increase or decrease with age and symptoms.
(3) indications:
Generally, loxoprofen sodium (as anhydrous substance) 60mg is given orally to adults once symptoms appear.
It should be increased or decreased with age and symptoms, but in principle, twice a day, with a maximum of 180 mg per day. In addition, when fasting should not take medicine, or follow the doctor's advice.
Adverse reactions According to literature reports (this item includes the reports of adverse reactions that can not calculate the incidence), 409 cases (3.03%) reported adverse reactions, mainly including digestive system symptoms (stomach and abdominal discomfort, stomachache, nausea and vomiting, loss of appetite, etc. 2.25%), edema and edema (0.59%), rash and urticaria (0.21%), drowsiness (0.10%), etc.
1. Major adverse reactions (incidence unknown)
(1) Shock: shock may occur, so attention should be paid to observation. If there is any abnormality, the drug should be stopped immediately and appropriate treatment should be taken.
(2) Hemolytic anemia, leucopenia, thrombocytopenia may occur, so blood examination should be carried out and other attention should be paid to observation, if there is any abnormality, the drug should be stopped immediately and appropriate treatment should be given.
(3) Mucocutaneous syndrome may occur, so attention should be paid to observation. If there is any abnormality, the drug should be stopped immediately and appropriate treatment should be given.
(4) Acute renal insufficiency, nephrotic syndrome and interstitial nephritis may occur, so we should pay attention to observation. If there is abnormality, we should stop taking drugs and give appropriate treatment. As hyperkalemia may occur with acute renal insufficiency, special attention should be paid to the use of this drug.
(5) Congestive heart failure may occur. If the chest X-ray is abnormal, the treatment should be stopped.
(6) Interstitial pneumonia: interstitial pneumonia with fever, cough, dyspnea, chest X-ray abnormalities, eosinophilia, etc. may occur. If such symptoms occur, the drug should be stopped immediately and appropriate treatment should be given such as adrenocortical hormone preparation.
(7) Gastrointestinal bleeding: severe peptic ulcer or gastrointestinal bleeding of the large intestine or small intestine, such as hematemesis, melena, and hematochezia, sometimes accompanied by shock. Patients should pay attention to observation, if abnormal, should immediately stop medication and appropriate disposal.
(8) Digestive tract perforation may occur. If upper abdominal pain or abdominal pain occurs, the drug should be stopped immediately and appropriate treatment should be taken.
(9) Liver dysfunction, jaundice: can appear ast (got), ALT (GPT) and γ - GTP increased, accompanied by jaundice of liver dysfunction or sudden hepatitis. Attention should be paid to the observation. If there is any abnormality, the drug should be stopped immediately and appropriate treatment should be done.
(10) Asthma attack: asthma attack and other acute respiratory disorders may occur. Attention should be paid to the observation. If there is any abnormality, the drug should be stopped immediately and appropriate treatment should be done.
(11) Aseptic meningitis: aseptic meningitis may occur (fever, headache, nausea, vomiting, neck rigidity, blurred consciousness, etc.). Attention should be paid to the observation. If there is any abnormality, the drug should be stopped immediately and appropriate treatment should be taken. (especially patients with systemic lupus erythematosus or mixed connective tissue disease are prone to adverse events.)
2. Major adverse reactions of other drugs of the same kind
Aplastic anemia: it is reported that other non steroidal anti-inflammatory analgesics may cause aplastic anemia.
3. Other adverse reactions
Taboo: ·1. Patients with active peptic ulcer / bleeding or previous ulcer / bleeding (peptic ulcer will worsen due to inhibition of prostaglandin biosynthesis and reduction of gastric blood flow). (refer to [precautions].
2. Patients with severe hematological abnormalities (may cause platelet dysfunction and make it worse).
3. Patients with severe liver function damage (there are reports of adverse reactions of liver damage, which may worsen). Patients with severe renal dysfunction (acute renal insufficiency, nephrotic syndrome and other adverse reactions).
4. Patients with severe cardiac insufficiency (due to inhibition of renal prostaglandin biosynthesis, resulting in edema, increase of circulating fluid volume, increase of cardiac workload, which may worsen symptoms).
5. Patients with a history of allergic reaction to the ingredients of this product.
6. Aspirin asthma (asthma attack induced by nonsteroidal anti-inflammatory analgesics, etc.) or patients with previous history [can induce aspirin asthma attack].
7. Late pregnant women (refer to the item of medication for pregnant women and lactating women).
8. It is forbidden to treat perioperative pain during coronary artery bypass grafting (CABG).
9. Patients with history of gastrointestinal bleeding or perforation after using NSAIDs.
Matters needing attention: 1. Use drugs cautiously (the following patients should use drugs cautiously)
(1) Patients with a history of peptic ulcer [can cause ulcer recurrence].
(2) For patients with peptic ulcer caused by long-term administration of non steroidal anti-inflammatory analgesics, it is necessary to use this product for a long time and treat them with misoprostol [misoprostol is used to treat peptic ulcer caused by non steroidal anti-inflammatory analgesics, but there are also peptic ulcer resistant to misoprostol treatment. Therefore, when using this product continuously, we should closely observe the condition and be cautious Re administration].
(3) Patients with abnormal blood or previous history [easy to cause hemolytic anemia and other adverse reactions].
(4) Patients with liver damage or a history of liver damage [can worsen or relapse].
(5) Patients with renal damage or previous history [can cause edema, proteinuria, serum creatinine rise, hyperkalemia and other adverse reactions].
(6) patients with hypertension and / or heart failure * such as fluid retention and edema should be cautious.
(7) Patients with a history of allergy.
(8) Patients with bronchial asthma [worsen the condition].
(9) Patients with ulcerative colitis [potentially worse].
(10) Patients with Crohn's disease [potential for deterioration].
(11) The elderly [refer to [medication for elderly patients].
2. Important and basic attention
(1) we should pay attention to the treatment of anti-inflammatory analgesics, which is symptomatic therapy rather than etiological therapy.
(2) when this product is used in chronic diseases (rheumatoid arthritis, osteoarthritis), the following matters should be considered.
a. For long-term medication, clinical examination (urine examination, blood examination and liver function examination, etc.) should be carried out regularly. In case of abnormality, the dosage should be reduced or stopped.
b. The treatment methods other than drug therapy should also be considered.
(3) the following items should be considered when this product is used for acute diseases.
a. Acute inflammation, pain and fever were considered.
b. In principle, avoid long-term use of the same drug.
c. If there is etiological treatment, it should be used.
(4) closely observe the patient's condition and pay attention to the occurrence of adverse reactions. Sometimes there will be excessive hypothermia, collapse and cold limbs. Therefore, especially for the elderly with high fever or patients with consumptive diseases, close attention should be paid to observe the condition of patients after administration.
(5) it may cover up the symptoms of infection, so when it is used for inflammation caused by infection, it should be combined with appropriate antibiotics, pay attention to observation, and be cautious in administration.
(6) It is better to avoid the combination with other anti-inflammatory analgesics.
(7) the elderly should pay special attention to the occurrence of adverse reactions, and only use the necessary minimum dose.
(8) According to the need of controlling symptoms, the use of the lowest effective dose in the shortest treatment time can minimize the adverse reactions.
(9) Gastrointestinal bleeding, ulcers and perforation can occur at any time during the treatment with all NSAIDs, and the risk can be fatal. These adverse reactions may or may not be accompanied by warning symptoms, regardless of whether the patient has a history of gastrointestinal adverse reactions or serious gastrointestinal events. Patients with previous gastrointestinal history (ulcerative colitis, Crohn's disease) should be cautious in the use of non steroidal anti-inflammatory drugs, so as not to worsen the disease. The drug should be stopped when gastrointestinal bleeding or ulcer occurs. The risk of adverse reactions, especially gastrointestinal bleeding and perforation, can be fatal in elderly patients.
(10) Clinical trials of COX-2 selective or non selective NSAIDs with a duration of up to 3 years have shown that this product may increase the risk of severe cardiovascular thrombotic adverse events, myocardial infarction and stroke, and its risk may be fatal. All NSAIDs, including COX-2 selective or non selective drugs, may have similar risks. Patients with cardiovascular disease or cardiovascular risk factors have a higher risk. Doctors and patients should be alert to such events even if they have no previous cardiovascular symptoms. The patient should be informed of the symptoms and / or signs of severe cardiovascular safety and the steps to be taken if they occur. Patients should be alert to symptoms and signs such as chest pain, shortness of breath, weakness and vagueness of speech, and should seek medical help immediately after any of the above symptoms or signs occur.
(11) Like all non steroidal anti-inflammatory drugs (NSAIDs), this product can cause new onset hypertension or aggravate existing hypertension symptoms, any of which can lead to an increase in the incidence of cardiovascular events. When patients taking thiazides or loop diuretics take non steroidal anti-inflammatory drugs (NSAIDs), the efficacy of these drugs may be affected. Patients with hypertension should be cautious in the use of non steroidal anti-inflammatory drugs (NSAIDs), including this product. Blood pressure should be closely monitored at the beginning and throughout the treatment.
(12) NSAIDs, including this product, may cause fatal and serious skin adverse reactions, such as exfoliative dermatitis, Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (ten). These serious events can occur without warning. Patients should be informed of the symptoms and signs of severe skin reactions, and discontinue the product when skin rashes or other signs of allergic reactions appear for the first time.
3. Other precautions
It has been reported that long-term use of NSAIDs can lead to temporary infertility in women.
Medication for pregnant and lactating women: 1. Pregnant women or women who may be pregnant should weigh the advantages and disadvantages of medication (the safety of medication during pregnancy has not been established).
2. Due to the reports of delayed delivery and fetal ductus arteriosus stenosis in animal experiments (rats), it is forbidden for women in late pregnancy.
3. Lactation women should avoid medication, and stop breastfeeding when medication is necessary (the rat experiment reports that this product can secrete milk).
Medication for children
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