Pharmaceutical Intermediate 6-Apa From Sinopharm with Fast Stock Delivery CAS 551-16-6

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP
• Suitable for: Intermediates
• State: Solid
• Purity: >99%
• Model NO.: FUL-PID0025
• CAS: 551-16-6
• Mf: C8h12n2o3s
• Fw: 216.25
• Name: Intermediate 6-Apa
• Packing: Drum
• Transport Package: Drum
• Specification: 25kgs/drum
• Origin: China
• Production Capacity: 100000000kgs/Month

Product Description

Item name: 6-APA
Other names: 6-Aminopenicillanic acid/6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-APA
Cas No.:  551-16-6
MF:C8H12N2O3S
FW: 216.25 6-Aminopenicillanic acid/6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-APA

6-APA is used as precursor for antibiotic compounds ampicillin and amoxicillin. Antibiotic synthesis of 6-APA can be augmented with a supersaturated solution of nucleophiles. Other methods for enhancing effectiveness involves diminishing ionic strength in a reaction mixture along with the addition of 2-butanol.

6-Aminopenicillanic acid(6-APA) and 7-aminocephalosporanic acid(7-ACA) are very important intermediates for synthetic antibiotics, and they are produced from penicillin and cephalosporin by the action of penicillin amidase and cephalosporin C amidase, respectively.

6-APA was found in corn steep liquor fermentations of Trichophyton mentagrophytes, Aspergillus ochraceous, and three strains of Penicillium sp. 6-APA was not detected in fermentations of Epidermophyton floccosum although penicillins were produced. 6-APA formed a large part of the total antibiotic production of T.

From Wikipedia, the free encyclopedia

 

6-Aminopenicillanic acid

Names
Preferred IUPAC name (2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Identifiers
CAS Number	551-16-6
3D model (JSmol)	Interactive image
ChEBI	CHEBI:57869
ChemSpider	10611
ECHA InfoCard	100.008.177
EC Number	208-993-4
PubChem CID	11082
UNII	QR0C4R7XVN
CompTox Dashboard (EPA)	DTXSID7046097
show InChI
show SMILES
Properties
Chemical formula	C8H12N2O3S
Molar mass	216.26 g·mol^−1
Appearance	colourless
Melting point	198 °C (388 °F; 471 K)
Solubility in water	0.4 g/100 mL
log P	0.600
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).  verify (what is  ?) Infobox references

6-APA ((+)-6-aminopenicillanic acid) is a chemical compound used as an intermediate in the synthesis of β-lactam antibiotics. The major commercial source of 6-APA is still natural penicillin G: the semi-synthetic penicillins derived from 6-APA are also referred to as penicillins and are considered part of the penicillin family of antibiotics.^[1]

In 1958, Beecham scientists from Brockham Park, Surrey, found a way to obtain 6-APA from penicillin.^[2] Other β-lactam antibiotics could then be synthesized by attaching various side-chains to the nucleus.^[3] The reason why this was achieved so many years after the commercial development of penicillin by Howard Florey and Ernst Chain lies in the fact that penicillin itself is very susceptible to hydrolysis, so direct replacement of the side-chain was not a practical route to other β-lactam antibiotics.^{[citation needed]}

References[edit]

1. ^ Patrick GL (2017). Medicinal Chemistry (6th ed.). Oxford, UK: Oxford University Press. p. 425. ISBN 978-0198749691.
2. ^ Batchelor, F. R.; Doyle, F. P.; Nayler, J. H. C.; Rolinson, G. N. (1959). "Synthesis of Penicillin: 6-Aminopenicillanic Acid in Penicillin Fermentations". Nature. 183 (4656): 257-258. Bibcode:1959Natur.183..257B. doi:10.1038/183257b0. PMID 13622762. S2CID 4268993.
3. ^ F.P. Doyle, J.H.C. Nayler, G.N. Rolinson US Patent 2,941,995, filed July 22, 1958, granted June 21, 1960. Recovery of solid 6-aminopenicillanic acid.

 

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Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.


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