Tablets for Edema Disease Excretes Excessive Sodium and Water in The Body

• Customization: Available
• Transport Package: Carton
• Specification: 20x15x15cm
• Model NO.: CF070
• Origin: China
• Production Capacity: 100000/Month

Product Description

[Drug name]



General name: Hydrochlorothiazide Tablets



Product Name: Hydrochlorothiazide Tablets (Yunpeng)



Hydrochlorothiazide Tablets



Pinyin full code: Qinglvsaiqinpian (Yunpeng)



Main Ingredient Hydrocloxazine.



"Into a"



Chemical name: 6-chloro-3, 4-dihydro-2H-1,2, 4-benzothiadiazine-7-sulfonamide-1, 1-dioxide



Molecular Weight: C7H8ClN3O4S2



This product is a white piece.



1. Edema disease excretes excessive sodium and water in the body, reduces extracellular fluid volume, and eliminates edema. The common ones include congestive heart failure, cirrhosis ascites, nephrotic syndrome, edema of acute and chronic nephritis, early stage of chronic renal failure, sodium and water retention caused by corticosteroid and estrogen therapy. 2. Hypertension can be used alone or in combination with other antihypertensive drugs, mainly for the treatment of essential hypertension. 3. Central or renal diabetes insipidus. 4. Nephrolithiasis is mainly used to prevent the formation of calcium-containing stones.



Specification model 25mg*100s



[Usage and Dosage] 1. Adults usually take oral dosage. Treatment of edema disease, 25~50mg each time, 1~2 times a day, or every other day treatment, or take 3~5 days a week. For the treatment of hypertension, take 25~100mg daily, divided into 1~2 times, and adjust the dose according to the antihypertensive effect. 2. Children are often taken orally. 1~2mg/kg per day according to body weight or 30~60mg/m2 per body surface area, divided into 1~2 times, and adjust the dose according to the efficacy. For infants younger than 6 months of age, the dose can be up to 3mg/kg daily.



[Adverse Reactions] Most adverse reactions are related to dose and duration. (1) Side effects caused by water and electrolyte disorders are common. Hypokalemia is more prone to be related to the potassium-expulsion effect of thiazide diuretics. Long-term potassium deficiency can damage renal tubules, severe potassium deficiency can cause vacuolar changes in renal tubules epithelium, and cause ectopias such as severe tachyarrhythmia. Hypochlorinated alkalosis or hypochlorinated or hypokalemic alkalosis, thiazides, especially hydrochlorothiazides, often significantly increase the excretion of chloride. In addition, hyponatremia is not uncommon, leading to central nervous system symptoms and aggravating renal damage. The decrease of blood volume and renal blood flow caused by dehydration may also lead to a decrease in glomerular filtration rate. Common clinical reactions to these water and electrolyte disturbances include dry mouth, dysphoria, muscle cramps, nausea, vomiting, and extreme fatigue and weakness. (2) Hyperglycemia. This drug can reduce glucose tolerance and increase blood glucose, which may be related to the inhibition of insulin release. (3) Hyperuricemia. Interfering with the excretion of uric acid in renal tubules, a few can induce gout attacks. Hyperuricemia may be overlooked because joint pain is usually absent. (4) Allergic reactions, such as rash, urticaria, etc., are relatively rare. (5) leukopenia or deficiency, thrombocytopenic purpura and other rare. (6) others, such as cholecystitis, pancreatitis, sexual dysfunction, light sensitivity, color vision disorders, but relatively rare.



[forbidden] is not clear.



Cross allergy: notes (1) with sulfa drugs, cefuroxime Sammy, bumetanide, carbonic anhydrase inhibitor has cross reaction (2) to the diagnosis of interference: can reduce glucose tolerance, blood sugar, urine sugar, blood bilirubin, blood calcium and blood uric acid, blood cholesterol, triglyceride, low density lipoprotein levels, magnesium, potassium, sodium, blood and urinary calcium reduced. (3) Use with caution in the following cases: (1) In patients with no urine or severe renal dysfunction, due to the poor effect of this class of drugs, the application of large doses can lead to drug accumulation and increased toxicity; diabetes mellitus; Hyperuricemia or a history of gout; (4) In severe liver function impairment, the disorder of water and electrolyte can induce hepatic coma; Hypercalcemia; hyponatremia; lupus erythematosus, can aggravate the condition or induce activity; pancreatitis; Sympatheticectomy (enhanced antihypertensive effect); Attending jaundiced infants. (4) Follow-up examination: Blood electrolyte; (2) blood sugar; blood uric acid; blood myoenzyme, urea nitrogen; (5) blood pressure. (5) Start with the lowest effective dose to reduce the occurrence of side effects and the secretion of reflex renin and aldosterone. (6) Patients with a tendency to hypokalemia should supplement potassium or use it together with potassium-preserving diuretics as appropriate. Please read the instructions carefully and follow the doctor's advice.



[Children's medication] Use with caution in infants with jaundice because of the elevated bilirubin in the blood.



[Drug use for elderly patients] The use of these drugs in the elderly is more prone to hypotension, electrolyte disturbance and renal function impairment.



[Medication for pregnant and lactating women] (1) It can pass the placental barrier. It has no preventive effect on hypertension syndrome. Therefore, pregnant women should use with caution. (2) It is not suitable for lactating women.



[Drug interaction] (1) Adrenocorticotropic hormone, adrenocorticotropic hormone, estrogen, amphotericin B (intravenous administration), can reduce the diuretic effect of this drug, increase the chance of occurrence of electrolyte disorders, especially hypokalemia. (2) Non-steroidal anti-inflammatory and analgesic drugs, especially indomethacin, can reduce the diuretic effect of this drug, which is related to the former inhibiting the synthesis of prostaglandin. (3) When combined with sympathetic amines, the diuretic effect is weakened. (4) Caleenamide (cholestylamine) can reduce the absorption of this drug in the gastrointestinal tract, so it should be taken 1 hour before or 4 hours after oral Caleenamide. (5) When combined with dopamine, the diuretic effect is enhanced. (6) When combined with antihypertensive drugs, the diuretic antihypertensive effect was enhanced. (7) When used in combination with antigout drugs, the latter should be adjusted in dose. (8) The effect of anticoagulants is weakened, mainly due to the decrease of body plasma volume after diuresis, the increase of coagulation factor level in blood, coupled with the improvement of liver blood supply and the increase of synthetic coagulation factor. (9) Reduce the effect of hypoglycemic drugs (10) Digitalis drugs, amiodarone and other drugs when combined with this drug, should be careful to prevent the side effects caused by hypokalemia. (11) Used together with lithium preparation, because this drug can reduce the removal of lithium from the kidney, increase the renal toxicity of lithium. (12) When used in combination with this drug, the conversion to formaldehyde is inhibited and the efficacy is decreased. (13) The enhancement of the effect of non-depolarizing muscle relaxants is related to the decrease of serum potassium. (14) When combined with sodium bicarbonate, the chance of low chlorine alkalosis increases.



[Drug overdose] Gastric lavage should be provided as early as possible, with support, symptomatic management, and close follow-up of blood pressure, electrolytes, and renal function.



(1) Influence on water and electrolyte excretion. Diuretic effect, urinary sodium, potassium, chlorine, phosphorus and magnesium plasma excretion increased, and reduced urinary calcium excretion. The mechanism of action of this class of drugs mainly inhibits the reabsorption of sodium chloride in the anterior and proximal tubules, thus increasing the Na+-K+ exchange and K+ secretion in the distal tubules and collecting tubules. The mechanism of action is not fully understood. All of these drugs can inhibit carbonic anhydrase activity to varying degrees, which may explain their effect on the proximal tubule. This class of drugs can also inhibit the activity of phosphodiesterase, reduce the intake of fatty acids to renal tubules and mitochondrial oxygen consumption, thus inhibiting the active reabsorption of Na+ and Cl- to renal tubules. Hypotensive effect. In addition to the diuretic effect of sodium excretion, there may be an extrarenal mechanism involved in blood pressure reduction, which may be to increase the excretion of Na+ in the gastrointestinal tract. (2) The effect on renal hemodynamics and glomerular filtration function. Because of renal tubule of water and Na + absorption decreases, malpighian tube pressure, as well as through the distal convoluted tubule of water and Na + increased, stimulate the macula densa through the tube - reflection, make the kidney in renin, angiotensin secretion to increase, cause renal vasoconstriction, renal blood flow decreased, glomerular goal and the ball small artery contraction, glomerular filtration rate also fell. The decrease of renal blood flow and glomerular filtration rate, as well as the absence of effect on loop henz, are the main reasons why the diuretic effect of this class of drugs is far less than that of loop diuretics.



[Pharmacokinetics] Oral absorption is rapid but incomplete, and intake can increase absorption, which may be related to the prolonged retention time of the drug in the small intestine. Part of the drug binds to plasma proteins and part enters red blood cells. Oral administration took effect for 2 hours, the peak time was 4 hours, and the duration of action was 6-12 hours. T1/2 was 15 hours, prolonged in patients with impaired renal function. The blood concentration of this drug decreased rapidly at the beginning of elimination phase after absorption, and decreased significantly later, which may be related to the drug entering into red blood cells at the later stage. It is mainly excreted by urine in its original form.



To shield from light and keep sealed.



[Packed] 100 tablets/bottle



[Effective period] 36 months



[Approval Number] National medicine approval H14020796



FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese

Our Ddvantage:
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2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages

Our Service
a)  Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.

Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.


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