Usage and dosage:The treatment should be based on the individual situation as far as possible. According to the clinical situation of patients, different doses of basic drugs were given. The patients with liver function injury should be monitored carefully, and the dosage should be reduced in severe cases.
The following doses are recommended for adults unless specifically directed by a physician:
1. Hypertension
Benazepril 30mg tablets, 30mg once a day.
Benazepril tablets 60mg, once a day.
2. Coronary heart disease
Chronic stable angina pectoris (exertional angina pectoris).
Benazepril 30mg tablets, 30mg once a day.
Benazepril tablets 60mg, once a day.
Usually the initial dose of treatment is 30 mg per day.
Course of treatment: the medication time should be decided by the doctor.
Medication: usually the whole tablet is swallowed with a small amount of liquid, and the medication time is not limited by the meal time.
Adverse reactions According to the frequency of CIOMS class III (placebo-controlled study: nifedipine n = 2661; placebo n = 1486; as of February 22, 2006; action study: nifedipine n = 3825; placebo n = 3840), the adverse drug reactions based on clinical studies were as follows:
The frequency of adverse reactions under "common" was less than 3%, except edema (9.9%) and headache (3.9%).
The following table summarizes the incidence of adverse reactions of drugs containing nifedipine according to the reports. Within each incidence group, adverse reactions were ranked in descending order of severity. The incidence was defined as common (≥ 1 / 100 to < 1 / 10), rare (≥ 1000 to < 1 / 100), and rare (≥ 10000 to < 1 / 1000). Only in the ongoing post marketing monitoring, adverse reactions whose incidence cannot be estimated are listed in the column "unknown".
It can be life-threatening
For dialysis patients with malignant hypertension and hypovolemia, the blood pressure can be significantly decreased due to vasodilation.
Taboo: ·This product is forbidden to be used in people who are known to be allergic to nifedipine or any ingredient in this product.
·Nifedipine is forbidden in cardiogenic shock.
·It is forbidden to use in patients with Kock sacs (ileostomy after rectocolonic resection).
·Nifedipine can not reach the effective plasma concentration when combined with rifampicin due to the enzyme induction. Therefore, it should not be used with rifampicin.
·Nifedipine is forbidden in pregnant women within 20 weeks and lactating women.
Matters needing attention: ·This product is forbidden to be used in people who are known to be allergic to nifedipine or any ingredient in this product.
·Nifedipine is forbidden in cardiogenic shock.
·It is forbidden to use in patients with Kock sacs (ileostomy after rectocolonic resection).
·Nifedipine can not reach the effective plasma concentration when combined with rifampicin due to the enzyme induction. Therefore, it should not be used with rifampicin.
·Nifedipine is forbidden in pregnant women within 20 weeks and lactating women.
1. for patients with heart failure and severe aortic stenosis, when the blood pressure is very low (severe hypotension with systolic pressure < 90mmHg), it should be very careful to take this product.
2. the product has non deformable substances, so patients with severe gastrointestinal stenosis should be cautious when using the product, because of the possible symptoms of obstruction. The occurrence of gastric stones is very rare and may require surgical treatment if it occurs.
3. there have been cases of obstruction in patients without gastrointestinal diseases.
4. when X-ray barium meal contrast, the product can cause false positive results (because of filling defect, it is mistaken for polyp).
5. the patients with liver function impairment should be strictly monitored and the dosage should be reduced in case of serious illness.
6. nifedipine was eliminated by metabolism of cytochrome P450 3A4 system. Therefore, drugs with inhibition or induction on cytochrome P450 3A4 system may change the first pass effect or clearance rate of nifedipine (see [drug interaction]). Therefore, the weak to medium effect inhibitors of cytochrome P450 3A4 system may increase the plasma concentration of nifedipine, for example:
-Macrolides antibiotics (e.g., erythromycin)
-Anti HIV protease inhibitors (e.g. litonavir)
-Pyrrole antifungal agents (e.g. ketoconazole)
-Antidepressants nefaridone and fluoxetine
-Quinuptin / daphtin
-Valproate
-Cimetidine
When nifedipine is used in combination with the above drugs, blood pressure should be monitored. If necessary, the dosage of nifedipine should be reduced.
7. impact on the ability of driving and operating machines: the drug response varies from person to person, so it may affect the ability of driving and operating the machine. This effect is especially obvious in the early treatment, drug replacement and drinking.
8. the product has an absorbable shell, which can make the drug release slowly and enter the human body for absorption. When the process is over, the complete empty pill can be found in feces.
9. nifedipine controlled release tablets contain photosensitive active ingredients, so the product should be kept away from light. The pills shall be moisture-proof and taken immediately after being taken out of the aluminum plastic plate.
Medication for pregnant and lactating women: Pregnant women and fertility
Pregnant women within 20 weeks of pregnancy are forbidden.
There are not enough studies on pregnant women.
Animal experiments showed that it had embryotoxicity, fetal toxicity and teratogenicity.
Although the incidence of perinatal asphyxia, cesarean section, preterm birth and intrauterine growth retardation has been reported to increase, the existing clinical evidence does not show any special prenatal risk. It is not clear whether these reports are caused by potential hypertension and its treatment or specific drug effects.
The information available is not enough to exclude the adverse effects of this product on fetuses and newborns. Therefore, women who are more than 20 weeks pregnant should carefully weigh the pros and cons when using this product, and only consider using this product when other treatment methods are not applicable or ineffective.
When pregnant women are given nifedipine and magnesium sulfate intravenously at the same time, their blood pressure may be too low to affect their mother and fetus, so close monitoring of blood pressure should be carried out.
In some cases of in vitro fertilization, nifedipine calcium antagonists are associated with reversible biochemical changes of sperm head, thus damaging sperm function. If there is no other reason for unsuccessful IVF, nifedipine calcium antagonists should be considered.
Lactating women
Nifedipine can enter breast milk. Since there is no report about the possible effect on infants, when nifedipine must be taken during lactation, lactation should be stopped first.
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Our Manufacture Factory Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
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