Minocycline Hydrochloride Capsule for Acute and Chronic Bronchitis

• Transport Package: Box
• Specification: 50mg*10tab/box
• Trademark: FUL
• Origin: China
• Model NO.: FC115-1
• Production Capacity: 10000PCS/ Month

Product Description

Item Name:Minocycline hydrochloride capsule
Molecular formula: C₂₃H₂₇N₃O₇·HCl

Item Description

Item nanme: Minocycline hydrochloride capsule
Item character: This product is yellow

Indication:
This product is applicable to the following infections caused by Staphylococcus, Streptococcus, pneumococci, Neisseria gonorrhoeae, dysentery, Escherichia coli, Klebsiella, proteus, Pseudomonas aeruginosa, Treponema pallidum and chlamydia
1. urethritis, nongonococcal urethritis (NGU), prostatitis, gonorrhea, cystitis, epididymitis, intrauterine infection, pyelonephritis, pyelonephritis, pyelonephritis, pyelonephraitis, etc.
2. superficial suppurative infection: acne, tonsillitis, periarthritis of shoulder, folliculitis, pyoderma, furuncle, boils, carbuncle, cellulitis, sweat glandular inflammation, lipocyst powder, papillary dermatitis, crevicitis, abscess, secondary infection of chicken eye, pharyngitis, dacryocystitis, blepharitis, granuloma, gingivitis, perigingivitis, perigingivitis, dental sinusitis of upper palate Infectious cyst of upper palate, periodontitis, otitis exterioris, vulvitis, vaginitis, trauma infection, postoperative infection.
3. deep suppurative diseases: mastitis, lymphadenitis, submandibular adenoitis, osteomyelitis and osteoinflammation.
4. acute and chronic bronchitis, asthmatic bronchitis, bronchiectasis, bronchopneumonia, bacterial pneumonia, atypical pneumonia, pulmonary suppuration.
5. syphilis.
6. otitis media, paranasal sinusitis, submandibular adenoitis.
7. diarrhea, enteritis, infectious food poisoning, cholangitis and cholecystitis.
8. peritonitis.
9. septicemia and mycosis.

Item specifications: 50mg*10tab/box

Usage and dosage: Oral administration.
The first dose for adults is 0.2g, and then 0.1g every 12 or 24 hours, or as directed by the doctor. Acne vulgaris 50mg, twice a day, 6 weeks as a course of treatment.
Patients with renal impairment
The total daily dose should not exceed 200 mg in 24 hours.

Adverse reactions
According to MedDRA system / organ classification, the adverse reactions were listed as follows with CIOMS frequency types:
Common: ≥ 1%
Unusual: ≥ 0.1% and < 1%
Rare: ≥ 0.01% and < 0.1%
Very rare: < 0.01%
Adverse reactions of system organ classification
Abnormal hematolymph system
Rare: eosinophil, leucopenia, neutropenia and thrombocytopenia;
Very rare: hemolytic anemia, whole blood cell reduction;
The incidence is uncertain: the granulocyte is lack;
Cardiovascular system abnormality
Very rare: myocarditis, pericarditis;
Abnormal ear and labyrinth
Rare: hearing impairment, tinnitus;
Endocrine system abnormality
It is very rare: abnormal thyroid function, brown black thyroid;
Gastrointestinal system abnormality
Rare: diarrhea, nausea, stomatitis, tooth discoloration (including adult tooth discoloration), vomiting;
It is very rare: dyspepsia, dysphagia, enamel development, enterocolitis, esophagitis, esophageal ulcer, glossitis, pancreatitis, pseudomembranous enteritis;
The incidence of the disease is uncertain: discoloration of the mouth (including tongue, lip and gum);
Systemic disease
Unusual: fever;
Very rare: discoloration of secretion;
Abnormal liver and gallbladder system
Rare: liver enzyme rise, hepatitis;
It is very rare: intrahepatic cholestasis, liver failure (including fatal), hyperbilirubinemia, jaundice;
The incidence of autoimmune hepatitis is uncertain;
Immune system abnormality
Rare: allergic / allergic reactions (including shock), including fatal;
The incidence is uncertain: hypersensitivity;
Infection and infection
Very rare: oral and anal genital tract candidiasis, vulvar vaginitis;
Metabolic and nutritional abnormalities
Rare: anorexia;
Abnormal muscles, connective tissue and skeletal system
Rare: joint pain, lupus like syndrome, myalgia;
It is very rare: arthritis, bone discoloration, systemic lupus erythematosus (SLE) deterioration, stiff joints, swelling of joints;
Abnormal nervous system
Common: dizziness (dizziness);
Rare: headache, insensitive sensation, abnormal sensation, brain pseudotumor, vertigo;
Very rare: the chimney protrudes;
The incidence of the disease was uncertain: convulsion, sedation;
Abnormal kidney and urinary system
Rare: the blood urea nitrogen (BUN) increased;
Very rare: acute renal failure, interstitial nephritis;
Abnormal reproductive system and breast
Very rare: glans inflammation;
Abnormal breathing, chest and mediastinum
Rare: cough, dyspnea;
It is very rare: bronchospasm, asthma deterioration, and lung eosinophil increase;
The incidence of pneumonia is uncertain: limited pneumonia;
Abnormal skin and subcutaneous tissue
Rare: hair loss, polymorphous erythema, nodule erythema, fixed drug eruption; Over coloring, photosensitive reaction, itching, rash and urticaria;
It is very rare: vascular edema, exfoliative dermatitis, over pigmentation of nails, Stevens Johnson syndrome, toxic epidermal necrosis, vasculitis;
After listing, thyroid cancer was reported in patients treated with minocycline, and the causal relationship between minocycline use and thyroid cancer has not been established.
The following syndromes have been reported. Some cases of these syndromes have been reported dead. Like other serious adverse reactions, if these syndromes occur, the drug should be stopped immediately:
·Allergic reaction syndrome, including epidermal response (such as rash or exfoliative dermatitis), eosinophil growth and one or more of the following: hepatitis, localized pneumonia, nephritis, myocarditis, pericarditis. Fever and lymphadenopathy may be present.
·Lupus like syndrome, including positive anti nuclear antibody; Joint pain, arthritis, stiffness or swelling of the joint; One or more of the following: fever, myalgia, hepatitis, rash, vasculitis· Serum disease like syndrome, including fever; Urticaria or rash; Joint pain, arthritis, stiffness and swelling. Eosinophil may be present.

Taboo:
It is forbidden to be allergic to any tetracycline drugs or any component of this product.

Matters needing attention:
Special warning
Allergic / anaphylactoid reactions (including shock and death) associated with minocycline hydrochloride administration are rare.
Pregnant women taking minocycline hydrochloride, like other tetracycline antibiotics, can cause fetal toxicity. Tetracyclines can cause permanent discoloration of teeth (yellow gray brown) during tooth development (from late pregnancy, infancy to early childhood). This adverse reaction is more common in patients with long-term medication, but it also occurs in patients with repeated medication in a short period of time. At the same time, enamel hypoplasia was also reported. Tetracyclines should not be used during tooth development unless the benefits outweigh the risks.
General notes
1. Patients with liver and kidney dysfunction, esophageal obstruction, the elderly, oral malabsorption or inability to eat, and patients with deterioration of general condition (easily leading to vitamin K deficiency) should be cautious.
2. Due to vestibular toxicity, this product is no longer used as a therapeutic drug for Neisseria meningitidis carriers and Neisseria meningitidis infections.
3. People who are allergic to this product may also be allergic to other tetracyclines.
4. Patients taking minocycline hydrochloride should be very careful when driving or operating dangerous machinery. During minocycline hydrochloride treatment, side effects of central nervous system were reported, including dizziness, dizziness or vertigo. These symptoms may disappear during treatment, usually after withdrawal. As it can cause dizziness and fatigue, automobile drivers, operators engaged in dangerous machine operation and high altitude operation should avoid taking this product.
5. Other very rare serious events in the use of minocycline include Stevens Johnson syndrome and toxic epidermal necrolysis. If any of the above serious skin reactions are suspected, minocycline hydrochloride should be discontinued.
6. It has been reported that the use of tetracycline drugs may cause brain pseudotumor (benign intracranial hypertension), usually clinical manifestations are headache and blurred vision. When tetracycline is used in infants, there are also reports of fontanel protrusion. Although most of the above and other related symptoms disappear after drug withdrawal, permanent sequelae may still exist.
7. This product will cause esophageal ulcer when it remains in the esophagus and disintegrates, so you should drink more water, especially before going to bed.
8. When patients with acute Neisseria gonorrhoeae urethritis are suspected to have primary or secondary syphilis, they should usually have dark vision examination. When other types of syphilis are suspected, they should have serological examination every month for at least 4 months.
9. The dosage of severe renal insufficiency patients should be lower than the usual dosage. If long-term treatment is needed, the blood drug concentration should be monitored.
10. Liver and kidney function should be checked regularly during medication.
11. This product may cause photosensitive dermatitis. The patient should be informed that it can cause severe sunburn reaction during taking tetracycline drugs, so the sun should be avoided during medication.
12. Patients with liver function damage: it is reported that minocycline hydrochloride has hepatotoxicity; Therefore, it should be used cautiously in patients with liver dysfunction and in combination with other hepatotoxic drugs.
13. Patients with renal impairment: the anti anabolic effect of tetracyclines can cause the increase of blood and urine nitrogen levels. In patients with severe renal impairment, high serum levels of tetracyclines can lead to azotemia, hyperphosphatemia and acidosis. If there is renal damage, even the usual oral and injection dose can lead to excessive drug accumulation in the body and liver toxicity.
14. Interference to laboratory examination indexes:
(1) When determining the concentration of catecholamine in urine (hingerty method), the interference of this product on fluorescence may make the determination result on the high side.
(2) It may increase the determination values of alkaline phosphatase, serum amylase, serum bilirubin and serum aminotransferase (AST, ALT).
15. Laboratory monitoring: patients should have regular physical examination of various system functions, including hematopoietic system, renal function and liver function.
16. This product can be taken with food, milk or carbonated beverage.
17. Store at controlled room temperature (20 ºC ~ 25 ºC) (68 ºC ~ 77 ºC) to avoid light, humidity and overheating.

Medication for pregnant and lactating women:
Animal studies have shown that tetracyclines can pass through the placenta and can be found in fetal tissues, resulting in toxic effects on fetal development (usually associated with delayed bone development). Treatment in the early pregnancy of animals may show signs of embryo poisoning.
Minocycline hydrochloride, like other tetracycline antibiotics, can pass through the placenta and cause fetal damage in pregnant women. If you are taking minocycline hydrochloride during pregnancy or if you are pregnant while taking minocycline hydrochloride, you should inform the patient of the potential risks of the drug to the fetus.
The use of tetracyclines during tooth development (late pregnancy) can cause permanent discoloration of teeth. Enamel hypoplasia has also been reported.
Taking tetracyclines in the second three months of pregnancy can form stable calcium complexes in fetal bones. A decrease in fibula growth rate was observed in immature infants treated with tetracyclines (25 mg / kg every 6 hours). The change of fibula growth rate could be recovered after drug withdrawal.
In the post marketing clinical experience reports, there are congenital malformations, including the occurrence of limb reduction.
Minocycline hydrochloride can be secreted in human milk; Therefore, it should be decided whether to stop breastfeeding or drug use.

FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese

Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages

Our Service
a)  Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.

Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.




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