Item nanme:Bumetanide Tablets Item character:This product is white
Indication:
1. Edema diseases include congestive heart failure, liver cirrhosis, kidney diseases (nephritis, nephropathy and acute and chronic renal failure caused by various reasons), especially when the effect of other diuretics is poor, the application of this kind of drugs may still be effective. Combined with other drugs in the treatment of acute pulmonary edema and acute fontanelle edema.
2. Hypertension. In the ladder therapy of hypertension, it is not the first choice for the treatment of essential hypertension, but when thiazides have poor efficacy. Especially when accompanied by renal insufficiency or hypertensive crisis, this kind of drugs is particularly suitable.
3. Prevention of acute renal failure is used to prevent insufficient renal blood perfusion caused by various reasons, such as water loss, shock, poisoning, anesthesia accident and circulatory insufficiency. Timely application while correcting insufficient blood volume can reduce the chance of acute tubular necrosis.
4. Hyperkalemia and hypercalcemia.
5. Dilution hyponatremia, especially when the blood sodium concentration is lower than 120mmol / L.
6. Antidiuretic hormone hypersecretion (SIADH).
7. Acute drug poisoning, such as barbiturates poisoning.
8. It may still be effective in some cases where furosemide is ineffective.
Item specifications:1mg*10s/box
Usage and dosage:Adults take it orally, 800 ~ 1200mg per day, 3 ~ 4 times, with a total of 30 ~ 50g as a course of treatment. The dosage for children is 4 ~ 6mg / kg at a time, four times a day
Adverse reactions The common ones are related to water and electrolyte disorders, especially in high-dose or long-term application, such as postural hypotension, shock, hypokalemia, hypochloremia, hypochloric alkalosis, hyponatremia, hypocalcemia, thirst, fatigue, muscle soreness, arrhythmia, etc.
There are few allergic reactions (including rash, even sudden cardiac arrest), dizziness, headache, nausea, nausea, vomiting, abdominal pain, diarrhea, pancreatitis, muscle rigidity and so on. Myelosuppression leads to granulocytopenia, thrombocytopenic purpura and aplastic anemia, liver dysfunction, abnormal sensation of the fingers, hyperglycemia, urine sugar positive, and increased diabetes. Hyperuricemia. Tinnitus and hearing impairment are often seen in high-dose intravenous rapid injection (the dose per minute is greater than 4 ~ 15mg), mostly temporary, and a few irreversible, especially when used together with other ototoxic drugs. In hypercalcemia, it can cause kidney stones. It is also reported that this drug can aggravate idiopathic edema. Occasionally, unmarried men have spermatorrhea and penile erection difficulties. Muscle soreness and chest pain can occur in large doses. The effect on glucose metabolism may be less than that of furosemide.
Taboo:
Not yet clear
Matters needing attention:
1. Cross allergy. People who are allergic to sulfonamides and thiazide diuretics may also be allergic to this drug.
2. interference with diagnosis: blood sugar and urine sugar are positive, especially in diabetes or prediabetes. Excessive dehydration can increase blood uric acid and urea nitrogen level temporarily. The concentrations of Na +, Cl -, K +, Ca2 + and Mg2 + in blood decreased.
3. Use with caution in the following situations: for those with no urine or serious renal function damage, the dosage of the latter needs to be increased, so the medication interval should be prolonged to avoid side effects such as ototoxicity; Diabetes mellitus; Hyperuricemia or history of gout; Severe liver function damage can induce hepatic coma due to water electrolyte disorder; Acute myocardial infarction, excessive diuresis can promote shock; Pancreatitis or history of the disease; Those with hypokalemia tendency, especially those with digitalis or ventricular arrhythmia: prostatic hypertrophy.
4. Follow up examination: blood electrolyte, especially in combination with digitalis or corticosteroids, liver and kidney function damage; Blood pressure, especially for antihypertensive, high-dose application or for the elderly; Renal function; Liver function; Blood glucose; Blood uric acid; Acid base balance; Listening.
5. Animal experiments suggest that this drug can delay fetal growth and ossification. The situation of newborns and lactating mothers is not clear. It can increase the excretion of urinary phosphorus and interfere with the determination of urinary phosphorus.
6. Athletes should use it with caution.
Medication for pregnant and lactating women:
1. This drug can pass through the placental barrier. Pregnant women, especially in the first 3 months of pregnancy, should try to avoid application. It has no preventive effect on pregnancy induced hypertension syndrome. Animal experiments show that this product can cause hydronephrosis, delay fetal growth and ossification, and increase abortion and fetal mortality.
2. This medicine can be secreted by milk. Lactating women should use it with caution.
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Our Manufacture Factory Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
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